You can do some minor adjustments on it.
Changing the tire size doesn't really change the shift points, it's just recalibrates the speedometer so that the trans changes gears at the right time, as well as corrects ABS errors.
I know on the 2010 that I just tuned, it allows you to adjust shift points based on MPH in each gear. It also allows you to adjust the downshift in the gears based on throttle position. You could also adjust the line pressure to firm up the shifts.
The biggest thing that it doesn't do is allow you to turn off the torque management.