Book time is 18.2 hours to R & R including swapping components (for a long block)
You're gonna have to pull the front end of the truck off (hood, grill, core support, front bumper, radiator, a/c condenser, lower valance, etc)
I've done them in Fords, and they're not as bad as you would think
The hardest part is the lack of space above the engine for a chain sling. Having access to the rear of the engine thru the cover is a nice feature when you're pulling an engine